Creon^® 10,000 and Creon^® Micro (5,000 lipase units per 100 mg scoop) allow you to prescribe a smaller dose to babies and younger children.

DOSING WITH CREON MICRO

• Initially 100 mg of Creon^® Micro (one measure equal to 5,000 lipase units) should be taken with each feed or meal¹
• Dose increases, if required, should be added slowly with careful monitoring of response and symptoms¹
• Titrate dose upwards as necessary to control symptoms and achieve adequate weight gain²
• Doses should not exceed 10,000 units of lipase/kg/day¹

Administration of Creon^® Micro

• In young infants: Creon^® Micro granules should be mixed with a small amount of apple juice and given from a spoon directly before the feed¹
• In weaned infants: granules should be taken with acidic liquids or soft foods (e.g. mixed with apple juice or apple puree), but without chewing, directly before the meal¹
• The apple juice should not be diluted¹
• Granules can be mixed with a small amount of milk and administered to the infant immediately¹
• The granules should not be added to the baby's bottle¹
• Crushing and chewing of the minimicrospheres or mixing with food or fluid with a pH greater than 5.5 can disrupt the protective enteric coating. This can result in early release of enzymes in the oral cavity and may lead to reduced efficacy and irritation of the mucous membranes¹
• Once mixed, give directly from a spoon ensuring that the infant swallows all the granules immediately and none are left on their infant’s face, around their mouth, or in their gums¹

Dosing with Creon^® 10,000

• Initially one or two capsules with each meal.
• Dose increases, if required, should be added slowly, with careful monitoring of response and symptomatology.

Administration of Creon^® capsules

• Encourage young children to swallow the capsules whole as early as they can, or
• Open the capsule and mix the granules with acidic liquids or soft food^1,3
• Care should be taken to ensure that no product is retained in the mouth.