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Supply constraint of Creon® 10000 Creon® 25000 (Pancreatin)
4th July 2024

As the marketing authorisation holder and distributor of Creon® in the UK, we were notified by our third-party manufacturing partner, Abbott, of a supply constraint of Creon® (pancreatin) in the UK.

This constrained supply is due to high global demand and reaching maximum manufacturing supply output.

Creon® is a biologic product with a natural variation of its raw material and is made using a complex manufacturing process. The complexity of the process means that the ability to increase manufacturing capacity in the short-term is limited.

There is a long-term strategic initiative between Viatris and Abbott to increase the supply output of Creon® at the manufacturing facility. This work has already begun with expected completion in 2026.

During this supply constraint, we hope to be able to supply approximately 90-95% of the average monthly demand for Creon® lipase units into the market each month, until this supply constraint is resolved.

If you require additional information or have any questions, please contact customer services on 01707 853100 or via email; productenquiries@viatris.co.uk. For medical enquiries please contact our medical information team on 01707 853 000 or via email; info.uk@viatris.co.uk.

UK-CRE-2024-00006 July 2024

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Dosing flexibility

The following doses of Creon® are available:

The dose of Creon® should be titrated following initiation to manage symptoms and maintain good nutritional status.

Healthcare professionals should focus on initiating patients on a sufficient dose using the least amount of capsules to treat the symptoms of PEI and restore nutritional status. It’s also important to educate patients to ensure they understand their disease and how to adjust dose according to their symptoms and diet, with the support of a dietitian.

Click here to offer support to your patients prescribed Creon®

Creon® doses can be titrated following initiation to ensure the individual patient has the most effective dose for them.

You will now leave the Creon patient website and go to the Creon Track site where you can join the Creon Track patient support programme

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Please continue to report suspected adverse drug reactions and device failures with any medicine or vaccine to the MHRA through the Yellow Card Scheme. It is easiest and quickest to report adverse drug reactions and device failures online via the Yellow Card website: https://yellowcard.mhra.gov.uk/ or search for MHRA Yellow Card in the Google Play or Apple App Store. Alternatively, you can report via some clinical IT systems (EMIS/SystmOne/Vision/MiDatabank) or by calling the Commission on Human Medicines (CHM) free phone line: 0800-731-6789.
Adverse reactions/events and device failures should also be reported to MAH at e-mail address: pv.uk@viatris.com.

This website is intended for UK healthcare professionals. If you are a patient who has been prescribed Creon® please click here

Viatris UK Healthcare Limited (company registration number 09189103), an English company with a registered office address at 20 Station Close, Potters Bar, Hertfordshire, EN6 1TL (VAT - 421 623 781).

Creon® is indicated for the treatment of pancreatic exocrine insufficiency.

CRE-2021-0769 December 2023.

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