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Dosing & administration in children

Creon® 10,000 and Creon® Micro (5,000 lipase units per 100 mg scoop) allow you to prescribe a smaller dose to babies and younger children.

DOSING WITH CREON MICRO

  • Initially 100 mg of Creon® Micro (one measure equal to 5,000 lipase units) should be taken with each feed or meal1
  • Dose increases, if required, should be added slowly with careful monitoring of response and symptoms1
  • Titrate dose upwards as necessary to control symptoms and achieve adequate weight gain2
  • Doses should not exceed 10,000 units of lipase/kg/day1

Administration of Creon® Micro

  • In young infants: Creon® Micro granules should be mixed with a small amount of apple juice and given from a spoon directly before the feed.
  • In weaned infants: granules should be taken with acidic liquids or soft foods (e.g. mixed with apple juice or apple puree), but without chewing, directly before the meal.
  • The apple juice should not be diluted.
  • Granules can be mixed with a small amount of milk and administered to the infant immediately.
  • The granules should not be added to the baby's bottle.
  • Once mixed, give directly from a spoon ensuring that the infant swallows all the granules immediately and none are left on their infant’s face, around their mouth, or in their gums.1

Dosing with Creon® 10,000

  • Initially one or two capsules with each meal.
  • Dose increases, if required, should be added slowly, with careful monitoring of response and symptomatology.

Administration of Creon® capsules

  • Encourage young children to swallow the capsules whole as early as they can, or
  • Open the capsule and mix the granules with acidic liquids or soft food1,3
  • Care should be taken to ensure that no product is retained in the mouth.

As children grow they are likely to increase their Creon® dose and take more capsules per meal. To help improve compliance and efficacy and to minimise pill burden, consider moving children to Creon® 25,000 capsules.

References

  1. Creon® Micro Summary of Product Characteristics. 2019.
  2. Munck A et al. Expert Rev Resp Med. 2010; 4(1): 47-56.
  3. Creon® Micro Patient Information Leaflet. 2015.

Dividing the dose between the begining, middle and the end of the meal may improve pancreatin and chyme mix.4

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