Mylan Connects

Efficacy & Tolerability

Many placebo-controlled studies have been conducted investigating the efficacy of Creon® in patients with Pancreatic Exocrine Insufficiency
(PEI).1-3  The data demonstrate that Creon® treats the symptoms of PEI and improves the nutritional status of patients with PEI and:

In all associated diseases, Creon® has been shown to:

  • increase fat absorption and reduce steatorrhoea
  • reduce stool frequency
  • improve stool consistency
  • be well tolerated

Creon® can achieve such improvements in patients with PEI because it has been developed to mimic the physiological pattern of pancreatic exocrine secretion. 4


A review of data from 15,000 patients with PEI and cystic fibrosis, chronic pancreatitis or pancreatic cancer found that side effects were present in < 1% of patients. The most commonly reported adverse reactions were gastrointestinal disorders which are mainly associated with underlying disease. According to the Creon® SPC, similar or lower incidences compared to placebo were reported for abdominal pain and diarrhoea.1-3,5


  1. Creon® Micro Summary of Product Characteristics. November 2016.
  2. Creon® 10000 Capsules Summary of Product Characteristics. January 2017.
  3. Creon® 25000 Capsules Summary of Product Characteristics. January 2017.
  4. Domínguez-Muñoz JE et al. Adv Med Sci. 2011; 56(1): 1-5.
  5. Imrie CW et al. Aliment Pharmacol Ther. 2010; 32(Suppl1): 1-25.
  6. Toouli J et al. Med J Aust. 2010; 193(8): 461-7.

Guideline Recommendation

… the cornerstone of therapy for PEI is replacement of pancreatic enzymes to allow for efficient digestion and nutrient absorption.4

Click here to view Creon®'s unique mode of action.

Follow the Link  Watch now

You will now leave the Creon patient website and go to the Creon Track site where you can join the Creon Track patient support programme

Would you like to proceed to the Creon Track registration website?


hcp popup title

Mylan Connects is an online platform for UK healthcare professionals.

Across the website you will find news, blogs and product information.

To request Creon® support materials and access webinars, videos and podcasts register to Mylan Connects today.

Please note that the website contains promotional and non-promotional material including educational content and resources to help you and your patients.